Ultrasmall Lanthanide Oxide Nanoparticles: A Novel Approach for Biomedical Imaging and Therapy

Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy (Woodhead Publishing Series in Biomaterial)

by Gang Ho Lee

5 out of 5

Language	:	English
File size	:	161686 KB
Text-to-Speech	:	Enabled
Screen Reader	:	Supported
Enhanced typesetting	:	Enabled
Print length	:	1573 pages
Paperback	:	96 pages
Item Weight	:	10.6 ounces
Hardcover	:	208 pages
Dimensions	:	6.14 x 0.38 x 9.21 inches

FREE

Nanotechnology has revolutionized the field of medicine, with a particular focus on developing novel imaging and therapeutic modalities. Among the promising materials being explored, ultrasmall lanthanide oxide nanoparticles (LNPs) have emerged as a promising platform for biomedical applications due to their exceptional properties.

Unique Properties of Ultrasmall LNPs

Ultrasmall LNPs possess a unique combination of properties that make them ideal for biomedical imaging and therapy:

• Small size: With diameters ranging from 1 to 10 nanometers, ultrasmall LNPs exhibit excellent tissue penetration and can target specific organs and cells.
• High surface area: The large surface area of ultrasmall LNPs provides ample space for functionalization with biomolecules, drugs, and imaging agents.
• Multimodal imaging: LNPs exhibit strong luminescence properties and can be used for optical imaging techniques such as fluorescence and bioluminescence. Additionally, they can be engineered for use in magnetic resonance imaging (MRI) and computed tomography (CT),enabling comprehensive anatomical and functional imaging.
• Photodynamic therapy: LNPs can generate reactive oxygen species (ROS) upon light irradiation, enabling photodynamic therapy for cancer treatment.

Applications in Biomedical Imaging

Ultrasmall LNPs offer significant advantages in biomedical imaging:

• Optical imaging: Ultrasmall LNPs can be functionalized with fluorescent dyes or quantum dots to enhance the sensitivity and specificity of optical imaging techniques. This enables real-time visualization of biological processes and the detection of disease markers at an early stage.
• Magnetic resonance imaging: LNPs can be doped with paramagnetic ions, such as gadolinium, to serve as MRI contrast agents. Their small size and high surface area allow for efficient delivery to target tissues, improving the diagnostic accuracy of MRI.
• Computed tomography: Ultrasmall LNPs can be functionalized with heavy elements, such as iodine or gold, for use as CT contrast agents. This allows for high-resolution anatomical imaging and the detection of pathological lesions.

Applications in Cancer Therapy

Ultrasmall LNPs have shown promising potential in cancer therapy:

• Drug delivery: Ultrasmall LNPs can be used to deliver chemotherapeutic drugs directly to tumor cells, reducing systemic toxicity and improving treatment efficacy.
• Photodynamic therapy: LNPs can generate singlet oxygen upon light irradiation, inducing cell death in cancer cells. This targeted approach minimizes damage to healthy tissues.
• Theranostics: Ultrasmall LNPs can be engineered to combine both imaging and therapeutic capabilities, enabling simultaneous diagnosis and treatment of cancer.

Ultrasmall lanthanide oxide nanoparticles represent a groundbreaking advancement in biomedical imaging and therapy. Their unique properties, including small size, high surface area, multimodal imaging, and therapeutic capabilities, provide numerous advantages for the early detection, diagnosis, and treatment of various diseases, particularly cancer. As research continues to explore the full potential of ultrasmall LNPs, they are expected to revolutionize healthcare and improve patient outcomes.

Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy (Woodhead Publishing Series in Biomaterial)

by Gang Ho Lee

5 out of 5

Language	:	English
File size	:	161686 KB
Text-to-Speech	:	Enabled
Screen Reader	:	Supported
Enhanced typesetting	:	Enabled
Print length	:	1573 pages
Paperback	:	96 pages
Item Weight	:	10.6 ounces
Hardcover	:	208 pages
Dimensions	:	6.14 x 0.38 x 9.21 inches

FREE